压力测量干粉吸入器使用门支室的最佳吸入配置:动态分析
Tetsuri Kondo1, Toshimori Tanigaki1, Makoto Hibino1
1Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan.
Journal of aerosol medicine and pulmonary drug delivery
|April 22, 2024
概括
优化压力计量剂量吸入器和式保持室 (pMDI+VHC) 的使用需要特定的吸入技术. 快速,强烈的吸入 (30-50L/分钟,0.4秒到峰值流量) 最大限度地提高了气溶的输送,提高了呼吸道药物效率.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 制药技术 制药技术 制药技术
- 生物医学工程 生物医学工程
背景情况:
- 带有门保持室 (pMDI+VHC) 的压力计量剂量吸入器对于有效和安全的药物输送至关重要.
- 吸入机动显著影响气溶释放特性和治疗疗效.
- 了解吸入动态和气溶输送之间的相互作用对于优化pMDI+VHC使用至关重要.
研究的目的:
- 为了研究特定的pMDI+VHC装置 (Aerochamber) 的空气动力学特性和气溶释放模式.
- 为了确定不同吸入机动对气道阻力和气溶输送的影响.
- 建立最佳的吸入参数,以最大限度地减少pMDI+VHC系统中的气溶沉积.
主要方法:
- 在体外研究测量模拟吸入期间的静态和动态气道阻力 (Raw).
- 气溶释放量是使用激光光度测仪在不同的吸收流 (WF) 配置下量化.
- 参数有所变化,包括WF强度,达到峰值流量的时间 (TPWF) 和吸入概况 (上升,稳定,下降).
主要成果:
- 气道阻力 (Raw) 与WF (10-50 L/min) 线性增加,在较低的流速下更的斜坡.
- 高峰WF (PWF) 和快速吸入 (TPWF=0.4秒) 一般会增加释放的气溶质量.
- 较长的TPWF减少了气溶质量和延长了释放时间;然而,最佳条件需要<0.4 L的提取体积.
结论:
- 对于有效的pMDI+VHC使用,建议吸入流量在30-50L/分钟之间.
- 快速吸入 (T PWF = 0.4 秒) 对于最大限度地增加气溶的输送至关重要.
- 实际建议包括尽可能快地吸入,持续时间小于2.0秒,体积超过0.55升.
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