自取样本的人类乳头瘤病毒测试对癌前检测和查在日本的有效性: ACCESS随机对照试验
Misuzu Fujita1,2, Kengo Nagashima3,4, Minobu Shimazu5
1Department of Health Research, Chiba Foundation for Health Promotion and Disease Prevention, Chiba, Japan.
International journal of cancer
|April 22, 2024
概括
日本 日本 日本 日本 日本.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 妇科 妇科医生 妇科
背景情况:
- 日本在预防宫癌方面面临着挑战.
- 在这种情况下,对人类乳头瘤病毒 (HPV) 自取样本测试的有效性仍未得到评估.
- 2级或更严重的宫内皮质瘤 (CIN2+) 是宫癌进展的关键指标.
研究的目的:
- 评估自取样HPV测试在增加宫癌查吸收方面的有效性.
- 评估自取样HPV测试对CIN2+检测的影响.
- 确定日本HPV检测自选自取样策略的可行性.
主要方法:
- 一项随机对照试验,涉及30-58岁的妇女,她们已逾期进行查.
- 干预组接受了细胞学或自取样HPV测试 (选择性);对照组接受了细胞学.
- 在各组之间比较了查吸收率和CIN2+检测率.
主要成果:
- 与对照组 (6.4%) 相比,自取样HPV测试组 (20.0%) 的查吸收率明显高.
- 对HPV阳性女性的细胞学选的遵守率很低,为46.8%.
- 两组之间没有观察到CIN2+检测的显著差异 (意向选分析).
结论:
- 自取样本HPV检测有效地增加了宫癌查参与率.
- 对后续细胞学选的遵守程度低,限制了癌前病变的检测.
- 改善后续合规性的策略对于最大限度地发挥HPV自取样的好处至关重要.
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