北印度流传的登革热病毒血清型和基因型:一项观察性研究
Om Prakash1, Anil Kumar Verma, Asutosh Paliwal
1Department of Microbiology, King George's Medical University, Lucknow, India.
Journal of vector borne diseases
|April 22, 2024
概括
这项研究追踪了2014-2022年北印度的登革热病毒血型和基因型. 登革热病毒 (DENV)-2是主要的血清型,随着时间的推移观察到DENV-1基因型的变化.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 登革热病毒 (DENV) 在全球范围内构成了重大公共卫生挑战.
- 了解流通的血清型和基因型对于有效的疾病监测和控制至关重要.
研究的目的:
- 调查印度北部流传的登革热病毒血清型和基因型.
- 在9年的时间内分析登革热病毒流行病学的趋势.
主要方法:
- 疑似登革热病例 (2014-2022) 的血清样本使用ELISA检测IgM抗体和NS1抗原.
- 阳性样本进行了血清型和基因型鉴定,以确定循环中的DENV菌株.
主要成果:
- 在41,476个疑似病例中,确认了超过12,000例登革热病例.
- DENV-2是主要的血清型 (66.40%),其次是DENV-3 (19.82%) 和DENV-1 (10.37%).
- 在2014年之后,DENV-1基因型V取代了基因型IV,病例在季风后达到顶峰.
结论:
- 在研究期间,DENV-1,DENV-2和DENV-3血清型在北印度传播.
- 主要的血清型和基因型随着时间的推移而变化,突出显示了登革热病毒流行病学的动态性质.
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