重复暴露于爆炸物对现役美国特种作战部队的影响
Natalie Gilmore1,2, Chieh-En J Tseng3, Chiara Maffei1,2,3
1Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
概括
在美国特种作战部队 (SOF) 中,重复暴露于爆炸与大脑变化有关,特别是在前带皮层. 这项研究突出了SOF人员爆炸引起的脑损伤的潜在诊断标志物.
科学领域:
- 神经科学是一个神经科学.
- 军事医学 军事医学
- 创伤性脑损伤 创伤性脑损伤
背景情况:
- 美国特种作战部队 (SOF) 经常面临爆炸性爆炸暴露,但其对大脑健康的长期影响,特别是重复爆炸暴露 (RBE),尚未完全理解.
- 缺少RBE相关脑损伤的诊断测试可能导致未识别的症状,并在关键恢复期间过早恢复工作.
研究的目的:
- 调查在现役美国SOF的累积爆炸暴露和各种健康结果之间的关系.
- 为了确定潜在的神经成像和蛋白质生物标志物来检测RBE诱导的大脑损伤.
主要方法:
- 通过综合神经成像 (结构性MRI,扩散MRI,功能MRI,TSPO PET-MRI,tau PET-MRI) 和认知/心理评估,评估了30名现役美国SOF.
- 分析了血液蛋白质组学和与这些措施相关的累积爆炸暴露,控制年龄,战斗暴露和的头部创伤.
主要成果:
- 较高的累积爆炸暴露与左侧正面前带皮层 (rACC) 的皮层厚度增加相关,这是一个统计学上显著的发现.
- 未经纠正的分析显示,更高的爆炸暴露与生活质量降低,功能连接性改变以及特定大脑区域 (rACC,insula,轨道前皮层) 的TSPO信号和皮质厚度变化之间存在关联.
结论:
- 面前环状皮质 (rACC) 似乎容易受到爆炸过压的影响.
- 基于网络的多式联网诊断方法显示,它有望用于检测在现役SOF中重复暴露于爆炸时造成的脑损伤.
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