以内镜超声波为基础的剪切波弹性图谱用于检测晚期肝脏疾病
Jad AbiMansour1, Jerry Yung-Lun Chin1, Jyotroop Kaur1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Department of Internal Medicine.
Journal of clinical gastroenterology
|April 22, 2024
概括
内镜超声波剪切波弹性图 (EUS-SWE) 显示出评估晚期肝病 (ALD) 的前景. 这种新的模式可以集成到标准的EUS中,以进行可靠的肝硬度测量.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 诊断技术 诊断技术 诊断技术
背景情况:
- 内镜超声波剪切波弹性成像 (EUS-SWE) 是一种测量肝硬度的新兴技术.
- 晚期肝病 (ALD) 需要准确的非侵入性评估方法.
研究的目的:
- 评估EUS-SWE用于检测晚期肝病 (ALD) 的诊断性能和可靠性.
- 评估EUS-SWE在识别晚期纤维化和门性高血压方面的准确性.
主要方法:
- 从2020年8月到2023年3月收集了前性EUS-SWE测量结果.
- 在患有和没有ALD的患者 (阶段≥3) 之间比较肝硬度.
- 后勤回归确定了影响EUS-SWE可靠性的因素;磁共振弹性图 (MRE) 用于在特定情况下的相关性.
主要成果:
- 患有ALD的患者的肝硬度明显高于对照组 (例如,右叶:24.8kPa与11.0kPa).
- 接收机操作员特征曲线 (AUROC) 下的区域用于ALD检测为0.73 (左叶) 和0.80 (右叶).
- 全身麻醉与可靠的EUS-SWE读数相关 (OR:2.73,P=0.040);左叶测量显示与MRE有显著的相关性.
结论:
- EUS-SWE是一种可行的技术,用于在晚期肝病的背景下评估肝硬度.
- 这种技术可以很容易地纳入常规内镜超声波检查中,用于ALD评估.
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