血清神经纤维光链与多发性硬化症患者的放射性疾病活动之间的时间关系
Robert J Fox1, Bruce A C Cree1, Jérôme de Sèze1
1From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA.
血清神经纤维光链 (sNfL) 水平与多发性硬化症 (MS) 疾病活性相关. 然而,大多数患有新增加多增强性病变的多发性硬化症患者在中断纳塔利祖马布治疗期间没有显示sNfL水平升高.
科学领域:
- 神经免疫学 神经免疫学
- 生物标志物发现发现
- 临床试验 临床试验
背景情况:
- 血清神经纤维光链 (sNfL) 是多发性硬化症 (MS) 疾病活动的生物标志物.
- sNfL与放射性MS疾病活动之间的动态关系需要进一步研究.
研究的目的:
- 评估sNfL水平与放射性MS疾病活性之间的相关性.
- 在RESTORE试验中,评估在纳塔利祖马布治疗中断期间的sNfL动态.
主要方法:
- 在纳塔利祖马布中断期间,每月对复发性多发性硬化症患者进行28周的MRI和sNfL测量.
- 一般化的估计方程模拟了纵向的sNfL趋势,并将其与加多增强 (Gd+) 病变相关联.
主要成果:
- 与没有Gd+病变的患者相比,sNfL水平增加 (12.1 vs 3.2 pg/mL).
- 观察到峰值sNfL的剂量依赖性增加,Gd+病变的数量增加.
- 然而,71%的Gd+病变患者的sNfL水平没有超过没有Gd+病变患者的95百分位.
结论:
- sNfL水平与MS中Gd+病变的存在相关.
- 大多数患有Gd+病变的患者没有表现出高SNfL,这表明SNfL作为监测MS活动的唯一生物标志物的局限性.


