严重的支气管肺发育不良会对早产婴儿的大脑生长产生不利影响
Taiki Shimotsuma1,2, Seiichi Tomotaki1, Mitsuyo Akita1
1Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Neonatology
|April 22, 2024
概括
在早产婴儿中,严重的支气管肺功能障碍 (BPD) 与大脑生长的减少有关,特别是大脑总和白质体积的减少,在18个月的校正年龄之前.
科学领域:
- 新生儿科学 新生儿科学
- 儿科神经学 儿科神经学
- 发育儿科 发育儿科
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿的慢性肺部疾病.
- 已知BPD会影响神经发育的结果.
- 严重的BPD对新生儿期以外的大脑生长的影响仍然不清楚.
研究的目的:
- 调查严重BPD对早产婴儿大脑生长的影响.
- 为了比较患有和没有严重BPD的婴儿从术语等效年龄 (TEA) 到18个月校正年龄 (CA) 的大脑生长.
主要方法:
- 63名早产婴儿 (42名严重的BPD,21名对照) 在TEA和18个月CA时接受了MRI.
- 使用婴儿大脑提取和分析工具箱 (iBEAT) 将大脑体积细分.
- 大脑体积和成长速度在各组之间进行了比较.
主要成果:
- 在TEA时没有观察到显著的大脑体积差异.
- 在18个月的CA时,患有严重BPD的婴儿的总大脑和脑白质量量显著减少.
- 从TEA到18个月CA的大脑生长速度在严重的BPD组中较低,对总大脑,大脑皮质和大脑白质.
结论:
- 患有严重BPD的早产婴儿在TEA和18个月CA之间表现出大脑生长的减少.
- 在这个关键时期,严重的BPD会对整体大脑发育和白质生长产生负面影响.
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