通过慢性小肠虫感染来调节肠上皮的透性
Thomas C Mules1,2, Jeffry S Tang1,3, Francesco Vacca1
1Malaghan Institute of Medical Research, Wellington, New Zealand.
Immunology and cell biology
|April 22, 2024
概括
慢性虫感染会动态地改变肠道上皮质的透性. 最初增加,透性在后期阶段下降,这表明在肠道疾病中治疗虫治疗的保存机制.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 寄生虫学的寄生虫学
背景情况:
- 肠道上皮质透性增加与许多疾病有关.
- 使用受控虫感染的虫疗法正在研究治疗这些疾病.
- 虫调节宿主免疫力,可能影响肠道屏障功能,但慢性影响尚不清楚.
研究的目的:
- 调查慢性虫感染期间肠上皮质透性和紧结蛋白表达的动态变化.
- 在小鼠模型和人类之间探索这些上皮质反应的保存性.
主要方法:
- 利用小鼠模型Heligmosomoides polygyrus来评估在急性和慢性感染阶段的上皮膜透性和紧结蛋白表达 (克劳丁,三细胞素).
- 在一个小人群中检查了肠道透性,这些人群在急性和慢性阶段经过实验感染了虫Necator americanus.
主要成果:
- 在小鼠中,急性感染 (1 周) 显示了对升调的阴茎类克劳丁-2 和降调的三细胞素的透性增加.
- 在老鼠的慢性感染 (6周) 显示,通过高调的结肠类克劳丁-1降低了透性.
- 人类数据显示,急性感染 (8周) 中小肠透率增加,慢性感染 (24周) 中结肠/全肠透率降低的趋势.
结论:
- 慢性虫感染诱导了动态的,特定阶段的肠道上皮质透性的变化.
- 这些变化涉及紧密结合蛋白,表明物种之间保留了宿主反应.
- 这些发现为治疗肠道屏障功能障碍相关疾病的虫治疗提供了潜在的机械基础.
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