重新审视潜在幻觉脆弱性的α静止状态动态:从隐藏的半马尔科夫建模的洞察力
Hanna Honcamp1, Michael Schwartze1, Maria Amorim2
1Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands.
Journal of neuroscience methods
|April 22, 2024
概括
隐藏的半马尔科夫模型 (HsMM) 强烈地描述了静止状态大脑活动动态. 虽然大脑状态是可重现的,但它们与听觉幻觉易感 (HP) 的联系需要在各种数据集上进一步调查.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 精神病学是一个精神病学.
背景情况:
- 休息状态 (RS) 的大脑活动是动态的,非静止的.
- 隐藏的半马尔科夫模型 (HsMM) 可以模拟这些复杂的RS动态.
- 以前的研究将HsMM的α频段状态动态与听觉幻觉易感 (HP) 联系起来.
研究的目的:
- 复制和验证关于HsMM大脑状态动态和HP的发现.
- 评估HsMM状态在数据集和数据集内部的可复制性.
- 调查阿尔法带大脑状态动态和HP之间的关联的可复制性.
主要方法:
- 使用隐藏的半马尔科夫模型 (HsMM) 来分析脑电图 (EEG) 静止状态数据.
- 检查了次秒时间尺度的大脑状态动态及其时空属性.
- 在不同的数据集和数据变异中评估大脑状态的可重现性及其与幻觉倾向的关联.
主要成果:
- 从EEGRS数据中,HSMM成功地确定了可复制和可概括的大脑状态.
- 尽管数据长度和电极数量的变化,大脑状态特征仍然很强大.
- 阿尔法带大脑状态动态和HP之间的直接关联在数据集中无法一致复制.
结论:
- HsMM提供了一种强大的方法来分析高时间分辨率的EEG RS动态.
- 大脑状态动态对个人HP差异的敏感性可能会受到数据记录和认知因素的影响,例如心灵漫游.
- 未来的研究应该考虑记录顺序和个人认知状态,在检查与幻觉脆弱性的联系时.
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