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Updated: Jun 28, 2025

Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells
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氨酸酸化CARM1促进其酶活性,并改变其向特异性

Hidehiro Itonaga1, Adnan K Mookhtiar1, Sarah M Greenblatt1,2

  • 1Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136, USA.

Nature communications
|April 22, 2024
PubMed
概括

雅努斯酶2 (JAK2) V617F突变酸化CARM1,增强其活性并改变基质特异性. 这种酸化对恶性髓状细胞增殖至关重要,并表明JAK2/CARM1双重向急性髓状白血病.

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