Salience网络连接性在6周大的婴儿中发生变化,患自闭症的可能性增加
Tawny Tsang1, Shulamite A Green2,3,4,5, Janelle Liu6
1Meta, Menlo Park, CA, USA.
Communications biology
|April 22, 2024
概括
婴儿突出网络 (SN) 大脑连接的早期差异预测自闭症谱系障碍 (ASD) 症状. 这可能解释了不典型的发展如何导致ASD,影响社会注意力和感官处理.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 自闭症谱系障碍研究研究
背景情况:
- 自闭症谱系障碍 (ASD) 与大脑连接受损有关,但早期发育机制尚不清楚.
- 突出网络 (SN) 对于引起注意至关重要,并且可能在ASD发展中发挥作用.
研究的目的:
- 调查婴儿的非典型突出网络连接是否预测ASD症状的发展.
- 探索SN连接性和社会注意力/感官处理之间的关系,在 ASD 的高和典型可能性的婴儿中.
主要方法:
- 使用神经成像检查了6周大的婴儿的突出网络连接,这些婴儿具有高和典型的ASD可能性.
- 与随后的ASD症状,社会注意力和感官处理相关联的SN连接模式.
主要成果:
- 患有自闭症的可能性较高的婴儿与感觉运动区域的SN连接性更强.
- 婴儿在典型的可能性显示较强的SN连接与前额外的社会关注区域.
- 观察到一个权衡:更高的感觉运动连接与较低的前额连接相关.
结论:
- 突出网络连接的早期变化与ASD漏洞有关.
- 这些发现为ASD的非典型发展轨迹提供了潜在的机制.
- 在注意力方面,SN的作用可能是ASD中社会和感官症状出现的基础.
相关概念视频
01:19Autism Spectrum Disorder
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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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01:14Piaget's Stage 1 of Cognitive Development
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The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
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