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Updated: Jun 28, 2025

Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells
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核孔形成中的Nup98的检查点功能由新型抑制纳米体提出

Mireia Solà Colom1,2, Zhenglin Fu1, Philip Gunkel1

  • 1Department of Cellular Logistics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

The EMBO journal
|April 22, 2024
PubMed
概括

研究人员开发了新的纳米体,以可视化和抑制核孔综合体 (NPC) 组装. 这些工具跟踪NPC生物发生,并识别参与脚手架形成和屏障组装的关键蛋白质.

关键词:
FG 阶段 FG 阶段核包裹是一个核包裹.核孔 核孔是一种核孔.核运输运输 核运输是核运输的重要组成部分.对于VHH的抗体来说,这是非常重要的.

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Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
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