单个神经元项体的多样化和不对称性模式在调节半球间连接性的过程中起作用
Yao Fei1,2, Qihang Wu2,3, Shijie Zhao4,5
1School of Automation, Northwestern Polytechnical University, Xi'an, China.
Nature communications
|April 22, 2024
概括
结核体 (corpus callosum) 是一个结核体.
科学领域:
- 神经科学是一个神经科学.
- 在Connectomics上,我们提供了连接.
- 计算神经科学是一种神经科学.
背景情况:
- 体促进半球间的通信.
- 传统上被视为同位素连接,它也支持复杂的异位素连接.
- 了解这些多样化的布线模式是必不可少的,但具有挑战性.
研究的目的:
- 在小鼠中划分体质体的解剖学和功能连接模式.
- 使用一种新的指标量化连接模式的复杂性.
- 调查投影异质性对功能连接性的影响.
主要方法:
- 利用公共AAV批量和单个神经元追踪数据进行解剖绘图.
- 在雄性小鼠中进行了广场成像,以评估功能连接.
- 开发了计算模型来分析连接模式及其功能影响.
主要成果:
- 单个神经元的追踪揭示了复杂的,密集的半球间异型连接.
- 引入了一个"异质性"指标来量化连接模式的复杂性.
- 计算建模显示,上游投影异质性影响下游的功能连接.
- 与半球内投射相比,半球间异形投射的异质性更高,导致功能连接的强度较低,但稳定性更高.
结论:
- 质体投射的异质性显著影响半球间的通信.
- 半球间异地形连接表现出不同的功能性质,受到投射异质性的影响.
- 这些发现突显了异型投影复杂性在大脑功能中的关键作用.
更多相关视频
09:44Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
Published on: March 8, 2024
4.7K
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
7.3K
相关概念视频
01:05Cerebral Hemispheres
327
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
327
01:28Lateralization
328
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
328