评估老年人多病症,非传染性疾病配置,虚弱表型和死亡风险之间的关系
Rafael Ogaz-González1,2, Eva Corpeleijn2, Rosa Estela García-Chanes3
1Department of Public Health, Faculty of Medicine, National Autonomous University of México, Sixth Floor, Building B, 411A Circuito Escolar, Copilco Universidad, Mexico City, Coyoacán, 04360, Mexico.
BMC geriatrics
|April 22, 2024
概括
虚弱与多种慢性疾病相结合,显著增加了老年人的死亡风险. 特定的非传染性疾病模式,而不仅仅是疾病的数量,更好地预测死亡率,当脆弱性是存在的.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 老年人面临着对疾病,慢性疾病和残疾的脆弱性增加,导致多病症和脆弱性.
- 多病症可以表现为不同的非传染性疾病 (NCD) 模式,可能影响脆弱性和死亡率.
- 特定的NCD配置,脆弱性和死亡风险之间的相互作用需要详细调查.
研究的目的:
- 分析非传染性疾病 (NCD) 结构对不同脆弱现象型的老年人死亡风险的影响.
- 为了比较NCD配置的死亡率预测能力与脆弱性存在的简单NCD计数.
主要方法:
- 利用了来自哥斯达黎加长寿和健康衰老研究队列 (CRELES) 的2662名60岁以上成年人的数据,追踪了5年.
- 采用探索性因子分析和聚类来识别不同的NCD配置.
- 应用Kaplan-Meier生存分析和Cox比例危险模型来评估死亡风险.
主要成果:
- 确定了四种NCD配置:"神经精神病"",代谢"",心血管"和"混合".
- "心血管"和"混合"配置显示,与累积三种或更多种非传染性疾病相比,死亡风险明显更高.
- 脆弱性独立预测高死亡风险,但在考克斯模型中与特定的NCD配置一起分析时,其意义下降.
结论:
- 脆弱性是一个关键的死亡率指标,特别是当与多病症同时发生时.
- 调查特定的NCD配置为死亡风险概况提供了比简单地计算疾病更细致的方法.
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