中部肥胖的MAFLD与结直肠腺瘤和高风险腺瘤的风险增加有关
Jingfang Xiong1, Yijun Wu2, Dongya Chen3
1Department of Geriatrics, Hangzhou Red Cross Hospital, Hangzhou City, Zhejiang Province, China.
BMC gastroenterology
|April 22, 2024
概括
与代谢相关的脂肪肝疾病 (MAFLD) 和中心肥胖症与结直肠腺瘤的发展有关. 与中心肥胖症结合的MAFLD增加了患结直肠腺瘤和高风险腺瘤的风险.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 结直肠腺瘤是结直肠癌的前体.
- 与代谢相关的脂肪肝疾病 (MAFLD) 越来越普遍,并与代谢功能障碍有关.
- MAFLD,肥胖和结直肠腺瘤风险之间的相互作用需要进一步调查.
研究的目的:
- 为了确定结直肠腺瘤的危险因素.
- 检查MAFLD,肥胖和结直肠腺瘤之间的联系,包括高风险亚型.
主要方法:
- 一项涉及1395名参与者的队列研究,分为结直肠腺瘤和对照组.
- 使用奇平方测试和后勤回归分析来比较特征并确定风险因素.
- 评估了MAFLD亚型,肥胖和腺瘤风险之间的关联.
主要成果:
- 结直肠腺瘤的独立风险因素包括年龄,肥胖,中心肥胖,高血压,糖尿病,脂肪肝,吸烟,体重指数,腰围,甘油三,高密度血糖,禁食葡萄糖和肝硬化症.
- 在中部肥胖症患者中,MAFLD与结直肠腺瘤风险增加显著相关 (P < 0.001).
- 肥胖,中心肥胖,糖尿病,脂肪肝和肝肥胖症是高风险腺瘤的独立风险因素,MAFLD和中心肥胖症显示高风险腺瘤的患病率更高.
结论:
- MAFLD和中心肥胖是结直肠腺瘤的独立风险因素.
- MAFLD和中心肥胖症的结合显著增加了患结直肠腺瘤和高风险腺瘤的风险.
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