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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
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一种基于Pfs48/45的疫苗来阻止Plasmodium falciparum传播:第一阶段,开放标签,临床试验

M Alkema1, M J Smit1, C Marin-Mogollon1

  • 1Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.

BMC medicine
|April 22, 2024
PubMed
概括

这项研究评估了一种新的阻断人类疟疾传播的疫苗 (R0.6C). 虽然它是安全和免疫性的,但需要进一步开发才能达到足够的抗体水平,以有效地减少疟疾传播.

关键词:
原菌 (Plasmodium falciparum) 是一种有毒的病毒.在 Pfs48/45/45 中使用.阻止传输 - 阻止传输.疫苗 疫苗 疫苗 疫苗

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...