在老年住院患者中分析了肉类和多病症的相关性分析
Wenjing Xia1, Kang Luo1, Ziwei Gu1
1Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
背景:
肌肉减少症与多病共存状态在老年人群中较为常见,目前大多数已有的临床研究主要关注特定专科疾病与肌肉减少症之间的关系,而针对肌肉减少症与多病共存之间关联的研究则相对较少。因此,我们希望探讨二者之间的关系。
方法:
研究对象为2016年3月至2021年9月期间在中国重庆医科大学第一附属医院老年病科住院的老年患者(年龄≥65岁),收集其病历资料。依据2019年亚洲肌少症工作组的诊断标准,阐明肌少症与多病共存之间的关系。
结果:
1. 本研究共纳入651名年龄≥65岁且患有两种及以上慢性疾病的老年人,其中46.4%患有肌肉减少症。 2. 慢性疾病数量与肌肉减少症关系的分析显示,患有4–5种慢性疾病的个体发生肌肉减少症的风险是患有2–3种慢性疾病个体的1.80倍(OR 1.80,95%CI 0.29–2.50),而患有≥6种慢性疾病的个体风险则为2–3种慢性疾病个体的5.11倍(OR 5.11,95%CI 2.97–9.08),在调整相关因素后,差异仍具有统计学意义。 3. Charlson合并症指数与骨骼肌质量指数、握力及6米步行速度相关,当评分达到5分及以上时,提示存在肌肉减少症的可能性。 4. 在调整老年人群中14种常见慢性疾病的若干协变量后,糖尿病(OR 3.20,95%CI 2.01–5.09)、脑血管疾病(OR 2.07,95%CI 1.33–3.22)、骨关节疾病(OR 2.04,95%CI 1.32–3.14)和恶性肿瘤(OR 2.65,95%CI 1.17–6.55)仍为肌肉减少症发生的危险因素。
结论:
在住院的老年患者中,慢性疾病数量越多,肌少症的患病率越高。当查尔森合并症指数(CCI)为5时,需关注住院老年患者中肌少症的发生。
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