多模式运动训练以减少多发性硬化症患者的虚弱:试点随机对照试验的研究协议
Tobia Zanotto1,2,3, Danya Pradeep Kumar4, Abbas Tabatabaei4
1Department of Occupational Therapy Education, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, 66160, USA. tzanotto@kumc.edu.
Pilot and feasibility studies
|April 22, 2024
概括
这项试点研究调查了一项多式运动计划,以减少患有多发性硬化症 (MS) 的人的脆弱性. 研究将评估该计划的研究.
科学领域:
- 神经学 神经学
- 老年学是指老年学的学科.
- 康复医学 康复医学 康复医学
背景情况:
- 在患有多发性硬化症 (pwMS) 的人群中,脆弱是常见的,不论年龄或残疾.
- 多发性硬化症的脆弱性与诸如跌倒和症状恶化等负面结果有关.
- 需要有效的策略来减少pwMS的脆弱性.
研究的目的:
- 评估pwMS多式模式炼计划的可行性.
- 确定该计划在减少脆弱性方面的初步有效性.
- 提供关于MS中虚弱的运动干预措施的新数据.
主要方法:
- 一项试点随机对照试验 (RCT) 涉及24名参与者 (40-65岁) 患有MS和虚弱.
- 参与者被随机分配到一个为期6周的多式运动计划 (认知运动康复 + 抵抗训练) 或等候名单对照.
- 评估包括体力活动评估脆弱性指数 (EFIP),跌倒风险,生活质量和生物标志物.
主要成果:
- 将收集有关多式联络运动计划可行性和初步有效性的数据.
- 将分析脆弱性,跌倒风险和生活质量的变化.
- 与脆弱性相关的生物标志物将在干预后进行评估.
结论:
- 这项研究是第一个评估针对MSMS脆弱性的有针对性的运动的RCT.
- 结果将提供关于多式联动运动对抗 pwMS 脆弱性的潜力的见解.
- 结果将为未来更大规模的干预提供信息.
相关概念视频
Exercise and Muscle Performance
1.4K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.4K
Parkinson's Disease: Treatment
264
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
264
Exercise and Cardiovascular Response
792
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
792


