运动训练减弱了肌肉线粒体对床上休息的基因组反应
Joshua A Cotter, Abel Plaza-Florido1, Gregory R Adams2
1Pediatric Exercise and Genomics Research Center, School of Medicine, University of California, Irvine, CA.
Medicine and science in sports and exercise
|April 23, 2024
概括
运动训练部分抵消了长时间的床上休息引起的基因表达变化,特别是在线粒体通路中. 然而,并非所有床上休息的分子效应都被对策完全逆转.
科学领域:
- 空间生理学空间生理学
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 长时间的床上休息会导致显著的生理脱节.
- 众所周知,运动对策可以减轻床上休息的一些负面影响.
- 了解这些适应的分子基础对于宇航员健康至关重要.
研究的目的:
- 在70天的床上休息期间,研究巨大的横向肌肉中的基因组和微RNA反应.
- 为了比较不同运动训练模式 (标准与飞轮) 作为对策的效果.
- 确定受床休息和运动影响的分子通路.
主要方法:
- 随机对照试验与22名健康男性分为三组:仅床上休息,床上休息与标准运动,床上休息与飞轮运动.
- 巨大的横向肌肉活检的基因和微RNA表达分析.
- 统计分析包括相互作用分析和丰富分析.
主要成果:
- 床上休息改变了超过2100个基因的表达,在床上休息组中占主导地位的下调.
- 运动训练减弱或逆转了511个基因的床上休息诱导的基因表达变化,而运动类型之间没有显著差异.
- 与线粒体相关的基因和通路受到显著影响,已知调节这些基因的12个microRNA被改变.
结论:
- 线粒体基因表达是长期卧床休息反应的关键分子组成部分.
- 运动对策可以部分缓解,但不能完全扭转床上休息的所有分子后果.
- 标准和飞轮运动模式都在减弱基因表达变化方面表现出类似的有效性.
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