通过基于的ICP后化学电离,与轨道-MS相结合,对非金属进行多元件检测
Grace Hahm1, Frenio A Redeker1, Kaveh Jorabchi1
1Department of Chemistry, Georgetown University, Washington, D.C. 20057, United States.
Journal of the American Society for Mass Spectrometry
|April 23, 2024
概括
这项研究引入了一种新的方法,用于检测多种非金属,使用感应合等离子体质谱法 (ICP-MS). 该技术提高了灵敏度,并解决了干扰,改善了和硫等元素的定量.
科学领域:
- 分析化学 分析化学
- 质谱测量质量谱测量
- 基本分析 基本分析
背景情况:
- 在ICP-MS中,对非金属 (F,Cl,S,P,Br,I) 的无标准定量受到等离子体内离子化困难和同离子干扰的挑战.
- 在ICP-MS中现有的非金属检测方法需要元素特异性干扰去除,限制了多元素分析.
- 这些非金属在药品和环境样本中的普遍存在需要改进检测技术.
研究的目的:
- 为增强多元非金属检测开发一种替代ICP-MS方法.
- 建立一个独立于元素的方法来解决非金属分析中的等离子干扰.
- 为了实现非金属的灵敏和准确量化,改进了检测极限.
主要方法:
- 分析物被引入一个ICP,形成后等离子体物种 (HF,HCl,H3PO3,H2SO4,HBr,HI).
- 这些物种通过纳米喷雾提供含离子进行化学电离,形成像BaF+,BaCl+,等等的离子.
- 用于离子检测的高分辨率质谱法,使元素独立干扰分辨率.
主要成果:
- 元素反应因子在两个数量级内是线性的,并且独立于分析物的化学结构.
- 对于Cl,Br,I和P的检测极限低于1ng/mL;F的检测极限为1.8ng/mL,S的检测极限为6.2ng/mL.
- 对电离机制的洞察力揭示了试剂离子和等离子产品的反应性趋势,指导了矩阵效应管理.
结论:
- 开发的方法提供了改进的非金属的多元素量化,提高了灵敏度和干扰去除.
- 了解电离机制为进一步优化技术提供了一条途径,以获得更好的性能.
- 这种方法可以更准确地分析与制药和环境科学相关的复杂矩阵中的非金属.
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