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Updated: Jun 28, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

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替代拼接用于可调节的蛋白质子单元的表达在所需的比率

Christel Aebischer-Gumy1, Pierre Moretti1, Timothee Brunstein Laplace1

  • 1Drug Substance Development, Ichnos Sciences SA (formerly Glenmark Pharmaceuticals SA), La Chaux-de-Fonds, Switzerland.

mAbs
|April 23, 2024
PubMed
概括

本研究介绍了一种替代拼接方法,用于控制单基因的蛋白质比率. 这种方法使得可调节的表达能够有效地产生多重蛋白质,包括双特异性抗体.

关键词:
替代性拼接是一种替代性的拼接.双曲曲的表达方式 (bicistronic expression)控制的表达方式优化比率优化比率优化可调节的子单位比率.

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