在9/11后的退伍军人中,快速眼动,睡眠行为障碍症状的发生率和预测因素
Melissa B Jones1, Juliann Tea1, Matthew Meyers1
1Mental Health Care Line (Jones, Jorge), Research Care Line (Jones, Villalon), and Medical Care Line (Agrawal), Michael E. DeBakey Veterans Affairs (VA) Medical Center, Houston; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences (Jones, Villalon, Jorge), and Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (Agrawal), Baylor College of Medicine, Houston; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tea); Division of Clinical Pharmacology, Department of Medicine, and Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Meyers); Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston (Li).
创伤后应激障碍 (PTSD) 和创伤性脑损伤 (TBI) 与退伍军人的快速眼动 (REM) 睡眠行为障碍 (RBD) 有关. 在一次查研究中,PTSD严重程度和TBI数量独立预测了RBD症状.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 军人卫生保健 军人卫生保健
背景情况:
- 创伤后应激障碍 (PTSD) 和创伤性脑损伤 (TBI) 在9/11后的退伍军人中很常见.
- 这些情况与快速眼动 (REM) 睡眠行为障碍 (RBD) 和退行性协核病变的风险增加有关.
研究的目的:
- 在9/11后的退伍军人中调查RBD症状的发生率和预测因素.
- 用一个验证的问卷来选退伍军人RBD.
主要方法:
- 休斯顿创伤和压力障碍转化研究中心 (TRACTS) 连续患者的横截面分析.
- 使用RBD问卷-香港 (RBDQ-HK) 的英语翻译进行选.
- 系统的图表审查以确定模仿RBD的睡眠障碍.
主要成果:
- 在119名退伍军人中,60%和55%的退伍军人根据不同的切断分数对RBD进行了查,结果呈阳性.
- 无变量分析显示,阳性RBD查和睡眠质量,TBI暴露和PTSD严重程度之间存在关联.
- 多变量分析确定了PTSD严重程度和TBI数量作为积极RBD查的独立预测因素.
结论:
- 对横睡症的跨学科评估至关重要.
- 需要对RBD查工具进行进一步的验证.
- 标准化报告REM睡眠没有atonia可以阐明PTSD,TBI,RBD和synucleinopathy风险之间的联系.
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