益生菌消费和肝肥胖症:来自NHANES 2011-2016年和门德尔随机化研究的结果
Yancheng Song1,2, Wencong Guo3,4, Junke Wang5
1Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
Frontiers in nutrition
|April 23, 2024
概括
益生菌酸奶的消费与降低肝硬化症 (HS) 风险有关. 最低风险的最佳摄入量约为每天0.4杯,这表明对肝脏健康有有益影响.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 益生菌在通过改善胰岛素抵抗和炎症来治疗代谢相关脂肪肝疾病 (MAFLD) 中显示出潜力.
- 益生菌对肝硬化症 (HS) 的进展的影响尚不清楚.
- 这项研究调查了大量人群中益生菌酸奶和HS之间的关联.
研究的目的:
- 检查益生菌酸奶消费与肝硬化症 (HS) 之间的关系.
- 为了确定最佳的酸奶摄入水平来降低HS风险.
- 使用孟德尔随机化探索潜在的因果关系.
主要方法:
- 对NHANES数据 (2011-2016) 的横截面分析,包括7,891名成年人.
- 使用肝硬化指数 (HSI) 评估的肝硬化 (HS).
- 进行了权重回归,子组,相互作用和门德尔随机化 (MR) 分析.
主要成果:
- 益生菌酸奶消费与HS有显著的反向关系 (OR=0.84).
- 观察到一个J形关系,HS风险最低在每天0.4杯酸奶附近.
- 门德尔随机化发现,酸奶消费与非酒精性脂肪肝疾病 (NAFLD) 之间没有因果关系.
结论:
- 益生菌酸奶的消费与肝硬化症 (HS) 的风险降低有关.
- 一个J形曲线表明一个特定的摄入水平,以获得最大的益处.
- 建议成年人每天摄入大约半杯酸奶,这可能有利于HS.
更多相关视频
08:35A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
Published on: May 18, 2021
6.3K
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
876
相关概念视频
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
01:22Probiotics
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...