和对暴露在黑页岩地区的人类肝脏和功能的影响
Minglong Li1,2,3, Liang Qiu4, Xunru Ai3
1Hubei Key Laboratory of Resources and Eco-environmental Geology Hubei Geological Bureau Wuhan China.
GeoHealth
|April 23, 2024
概括
可能会保护人类免受的毒性,即使在黑页岩地区的高暴露率. 这表明当前的风险评估可能需要对这些领域进行重新评估.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 人体生理学 人体生理学
背景情况:
- 动物研究表明, (Se) 可能减轻 (Cd) 在肝脏和脏中的毒性.
- 关于对毒性的保护作用的人类数据有限.
- 中国黑页岩地区的环境和含量较高.
研究的目的:
- 调查对高暴露黑页岩地区的人类对毒性的潜在对抗作用.
- 评估美国环境保护局 (USEPA) 在这些地区的风险评估方法的准确性.
- 评估高和暴露人群中的功能生物标志物.
主要方法:
- 在黑色页岩地区 (恩石和珠西县) 的横截面研究,土壤和大米中的Se和Cd含量较高.
- 在居民中测量血液和尿液 (Se) 和 (Cd) 水平.
- 对敏感的肝脏和功能生物标志物的分析 (血清肌素,囊素C).
主要成果:
- 居民血液和尿液中的Se和Cd水平显著升高,超过了安全摄入门.
- 尽管暴露很高,肝脏和脏的生物标志物仍然在健康范围内,这表明的潜在保护作用.
- 与朱居民相比,恩石居民的血清肌素和囊素C水平更高.
结论:
- 可能对人类的毒性产生对抗作用,即使在高暴露水平.
- 由于的影响,USEPA风险评估方法可能低估了黑页岩地区的风险.
- 高和暴露可能在一定程度上影响脏过功能,需要进一步调查.
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