在euthymia与躁狂发作期间,I型双相情绪障碍患者的嗅觉敏感度显著改善:一项纵向研究
Xianlin Liu1, Langjun Su1, Yingying Li1
1Department of Psychiatry, Shunde WuZhongpei Memorial Hospital, Foshan, Guangdong, China.
Frontiers in psychiatry
|April 23, 2024
概括
双极性障碍 (BD) 患者表现出嗅觉敏感性和识别能力受损,在缓解期间改善. 嗅觉识别可能是BD的标志物,灵敏度可以追踪治疗的有效性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物标志物 生物标志物
背景情况:
- 双极性障碍 (BD) 与嗅觉和血清瘤坏死因子-α (TNF-α) 的潜在变化有关.
- 在BD患者的同时嗅觉功能和血清TNF-α评估方面存在有限的研究.
- 在躁狂患者和euthymic BD I患者的纵向嗅觉功能仍然未得到充分研究.
研究的目的:
- 与健康对照人群相比,研究躁狂BD I患者的嗅觉功能 (灵敏度和识别) 和血清TNF-α.
- 评估BD I患者缓解期间嗅觉功能的纵向变化.
- 探索BD I. 嗅觉功能,临床症状,社会功能和血清TNF-α之间的相关性.
主要方法:
- 评估躁狂BD I患者 (n=44) 和健康对照 (n=32) 使用嗅觉敏感度 (OS) 和识别 (OI) 的Sniffin' Sticks测试,年轻躁狂评分表 (YRMS),全球评估功能 (GAF) 和血清TNF-α.
- 在缓解期间重新评估的BD I患者 (n=25).
- 在躁狂,性BD I和健康的对照组中比较了嗅觉功能和血清TNF-α;检查了相关性.
主要成果:
- 躁狂BD I患者的OS和OI明显低于健康对照组.
- 优性BD I患者的嗅觉敏感度恢复到与健康对照人相比的水平.
- 嗅觉敏感度的变化与YRMS得分的降低正相关,与疾病持续时间负相关;血清TNF-α在BD I患者中较低,但与嗅觉功能无关.
结论:
- 在躁狂BD I患者中,嗅觉敏感性和识别受损.
- 在BD I患者的嗅觉敏感性受损在缓解后是可逆的.
- 嗅觉识别可以作为BD的潜在诊断标记,而嗅觉敏感性可以表明治疗有效性和预后.
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