使用基于人口的SEER数据库对左侧和右侧结肠癌的生存趋势:从1975年到2019年的45年分析
Mark B Ulanja1, Kwabena Oppong Asafo-Agyei2, Vijay Neelam1
1CHRISTUS Ochsner St. Patrick Hospital, Lake Charles, Louisiana, USA.
Cancer medicine
|April 23, 2024
概括
左侧结肠癌 (LSCC) 显示出比右侧结肠癌 (RSCC) 更好的生存率. 现代化疗已经扩大了这种生存差距,有利于LSCC的结果.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 流行病学 流行病学
背景情况:
- 以前的研究报告了左侧结肠癌 (LSCC) 和右侧结肠癌 (RSCC) 之间的生存差异的混合结果.
- 在比较LSCC和RSCC存活率时,现有的研究往往没有考虑其他死亡原因.
研究的目的:
- 评估结肠癌因果特异性生存率 (CSS) 和总生存率 (OS) 基于瘤侧向性的趋势.
- 分析LSCC和RSCC之间的生存差异随着时间的推移,考虑到现代治疗的影响.
主要方法:
- 使用细灰竞争风险和考克斯模型进行分析.
- 分析了来自监测,流行病学和最终结果 (SEER) 数据库 (1975-2019) 的大量基于人口的队列.
- 根据采用现代化疗的情况,将研究期分为三段时间: 1975-1989年, 1990-2004年和 2005-2019年.
主要成果:
- 与RSCC相比,LSCC在最近的时期 (2005-2019) 显示出更高的特定原因生存率 (CSS).
- 在所有研究期间,LSCC始终显示出更好的整体存活率 (OS),无论癌症的阶段如何.
- 虽然LSCC早期的阶段最初的CSS较差,但随着时间的推移,这种风险会减弱;然而,遥远的LSCC始终具有优越的CSS.
结论:
- 与RSCC相比,LSCC与明显更好的生存结果有关.
- 采用现代化疗方案导致LSCC和RSCC之间的预后变得越来越差异化,有利于LSCC.
- 瘤侧向性应该是结肠癌临床试验招生考虑的关键因素.
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