布普伦诺芬会影响小鼠中因胰岛素诱导的急性胰腺炎的发病和严重程度
Sarah Jahangir1, Biswajit Khatua1, Nabil Smichi1
1Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, United States.
概括
延长释放布伦诺芬在急性胰腺炎 (AP) 的小鼠模型中降低了严重程度. 这种阿片类药物治疗减少了胰腺损伤和脂肪亡,但加快了脏损伤,并在注射部位引起皮肤刺激.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 实验医学是一种实验医学.
背景情况:
- 急性胰腺炎 (AP) 是一种普遍存在的疾病,缺乏向治疗,患者的治疗结果各不相同.
- 在AP的疼痛管理通常涉及阿片类药物,但它们的风险和益处是有争议的.
- 布普伦诺芬是一种常用的阿片类药物,研究了它对AP启动和进展的影响.
研究的目的:
- 在临床前小鼠模型中研究延长释放布诺芬对严重急性胰腺炎的发展和进展的影响.
- 评估布普伦诺芬对关键病理标志物和与AP相关的生理参数的影响.
主要方法:
- 一种严重的急性胰腺炎模型被诱导在遗传肥胖 (ob/ob) 鼠用interleukins 12和18 (IL12,18).
- 在AP诱导之前,延长释放布普伦诺芬被皮下注射.
- 在3天的时间里,对小鼠进行了监测,并比较了布普伦诺芬治疗组和对照组的结果.
主要成果:
- 布普伦诺芬显著降低了血清粉酶,脂酶,胰腺缩和脂肪缩.
- 该药物延迟了与AP相关的低血压和低温,但加速了损伤和呼吸系统抑郁.
- 在布普伦诺芬注射部位观察到皮肤炎症,表皮稀疏和亡的增加.
结论:
- 皮下延长释放布普伦诺芬在小鼠中对AP诱导和进展产生了多方面的干扰.
- 虽然减少了胰腺损伤的关键指标,但布普伦诺芬也改变了生理反应,并引起了局部注射部位反应.
- 需要进一步的研究来探索布普伦诺芬在AP管理中的治疗潜力和安全性.
更多相关视频
07:10Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
4.2K
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
514
相关概念视频
01:27Acute Pancreatitis I: Introduction
1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
01:24Chronic Pancreatitis I: Introduction
906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906
01:25Acute Pancreatitis I: Introduction
24
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
24
01:21Acute Pancreatitis II: Pathophysiology
46
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
46
01:25Chronic Pancreatitis I: Introduction
26
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26
01:21Chronic Pancreatitis II: Pathophysiology
30
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
30