脊柱功能化的二复合物用于催化升级乙醇和甲醇到异-布坦醇
Folasade J Sama1,2, Rachel A Doyle2, Benson M Kariuki1
1Cardiff Catalysis Institute, Cardiff University, Translational Research Hub, Maindy Road, Cathays, Cardiff, Wales, CF24 4HQ, UK. WassD@cardiff.ac.uk.
新的催化剂通过迈克尔的添加有效地将乙醇和甲醇转化为异醇. 催化剂6具有很高的选择性和稳定性,在这种重要的化学转化过程中获得了很好的产量.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 绿色化学 绿色化学
背景情况:
- 格尔贝特反应是提升酒精的关键转换.
- 开发高效和选择性催化剂用于酒精升级对于可持续的化学合成至关重要.
- 基于的复合物在酒精功能化中具有催化应用的潜力.
研究的目的:
- 开发用于将乙醇和甲醇升级为异醇的格尔贝特式升级的新型催化剂.
- 研究催化剂结构,特别是功能化供体群对催化剂活性和稳定性的影响.
- 在目标转换中实现高收益率和选择性.
主要方法:
- 合成与鲁协调的dppen (1,1-bis(diphenylphosphino) 乙烯) 复合物与各种氨基.
- 合成的复合物以乙醇/甲醇的催化试验,通过迈克尔的添加将其升级为异-布坦醇.
- 对反应产物的分析以确定产量,选择性和催化剂性能.
- 基于功能化供体组的存在,评估催化剂稳定性.
主要成果:
- 所有开发的催化剂在2小时内实现了超过50%的异布坦醇产量,具有>90%的选择性.
- 催化剂1表现出最高的活性,在2小时后产生74%的异butanol.
- 催化剂6表现出了卓越的表现,选择性接近100%,营业额为1000.
- 与未协调的功能化供体组的复合物相比,与非功能化类似物相比,催化剂稳定性得到了增强.
结论:
- 新型--胺催化剂对于格尔贝特型乙醇/甲醇升级为异-布坦醇的高效性.
- 催化剂6是一个显著的进步,提供近乎完美的选择性和高的催化剂周转率.
- 在催化剂结构中纳入功能化供体组增强了稳定性,为更强大的催化系统铺平了道路.
更多相关视频
10:39Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
Published on: August 23, 2018
06:46Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
相关概念视频
Hydroboration-Oxidation of Alkenes
Olefin Metathesis Polymerization: Overview
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists...
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
Preparation of Alcohols via Addition Reactions
The acid-catalyzed addition of water to the double bond of alkenes is a large-scale industrial method used to synthesize low-molecular-weight alcohols. An acidic atmosphere is required to allow the hydrogen in the water molecule to act as an electrophile and attack the double bond in an alkene. The addition of a proton to the double bond creates a carbocation intermediate. The proton preferentially bonds to the less substituted end of the double bond to create a more stable carbocation...
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
