在TIA管理 (ROTIA) 中坚定的Onyx
Ameer E Hassan1,2, Ahmed M Shoman1,3, Samantha Miller1
1Clinical Research Department, Valley Baptist Medical Center - Harlingen, Harlingen, TX, USA.
概括
坚决的奥尼克斯支架是一种可行的选择,用于管理耐火性内动脉样硬化疾病的复发性TIA,显示出高成功率和低并发症. 需要进一步的试验来证实这些发现.
科学领域:
- 神经学 神经学
- 干预心脏病学 干预心脏病学
- 血管外科 血管外科
背景情况:
- 医学管理是症状性内动脉样硬化疾病 (ICAD) 的第一线治疗方法.
- 对于耐火性ICAD病例,越来越多地考虑使用干预方法.
- 药物释放的Resolute Onyx (R-Onyx) 支架被评估用于治疗由于耐火性ICAD的复发性TIA的非标签性使用.
研究的目的:
- 评估Resolute Onyx药物释放支架的安全性和有效性,用于从耐火ICAD中复发TIA的患者.
- 评估支架后的周围手术并发症和长期缺血事件.
主要方法:
- 一个单一中心,追溯的病例系列20名患者接受R-Onyx血管塑性和支架治疗.
- 患者有复发的TIAs来自>70%的内动脉狭窄,尽管最大限度的医疗治疗.
- 结局包括手术前并发症和缺血性中风,直至支架后18个月.
主要成果:
- 20名患者接受了21个R-Onyx支架的成功部署,没有术前并发症.
- 在造后30天没有观察到任何复发性缺血事件.
- 在18个月后,没有发生缺血事件或支架静止.
结论:
- 坚决的奥尼克斯药物释放支架可用于管理耐火性ICAD中的TIA,显示出高技术成功率和低并发症率.
- 局限性包括回顾性,单中心设计.
- 有必要进行前性,多中心的随机试验,并进行更长的随访.
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