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Updated: Jun 28, 2025

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在工程化HCGL中,以计算为指导的低氨酸蛋白质变体的合理设计

Qian Zhang1, Shuai Fan1, Mengjia Tang2

  • 1NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Journal of agricultural and food chemistry
|April 23, 2024
PubMed
概括

改造的人类氨酸γ-酶 (hCGL) 突变体表现出增强的活性和热稳定性,为癌症治疗提供了潜力. 然而,需要谨慎的设计,以确保生物可用性和稳定性 in vivo.

关键词:
修改赛斯泰因的方法人类的cystathionine-γ-lyase被认为是一个可靠的药物.合理的设计理性的设计.热稳定性 热稳定性

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Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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