使用太赫兹时域光谱学,在张力下对人体皮肤进行表征
Baitong Chen1, Pengyan Zhang1, Keyu Tan1
1Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin, China.
Journal of biophotonics
|April 23, 2024
概括
这项研究提出了一种新的光谱分析方法,它结合了太赫兹时域光谱学 (THz-TDS) 和光学连贯性断层扫描 (OCT) 来进行体内人体皮肤监测. 该技术在各种皮肤紧张条件下准确地测量表皮和皮肤的特性.
科学领域:
- 生物医学光学 生物医学光学
- 生物物理学的生物物理.
- 医疗成像医学成像
背景情况:
- 对人类皮肤特性进行非侵入性体内监测对于诊断和治疗至关重要.
- 现有的方法可能缺乏精度或范围来分析复杂的皮肤结构及其对机械应激的反应.
- 太赫兹时域光谱 (THz-TDS) 和光学连贯性断层扫描 (OCT) 提供了互补的非电离成像和光谱能力.
研究的目的:
- 开发和验证一种结合THz-TDS和OCT光谱分析方法,用于体内皮肤的定量监测.
- 为参数提取建立光学反射的多层皮肤模型.
- 研究皮肤紧张对关键生物物理参数的影响.
主要方法:
- 开发一个光学反射的多层皮肤模型.
- 使用OCT进行初始表皮厚度测量.
- 通过将模型与实验THz-TDS信号相匹配,对皮肤参数 (折射率,厚度,传导系数) 的校准.
- 在不同的紧张条件下,研究皮肤参数的变化.
主要成果:
- 成功量化测量了表皮折射率,厚度和传导系数.
- 在体内精确确定皮肤折射率.
- 证明该方法在自然和紧张状态下评估皮肤特性的能力.
- 在体内皮肤分析中结合THz-TDS和OCT方法的验证.
结论:
- 综合的THz-TDS和OCT光谱分析方法为非侵入性,定量性在体内皮肤表征提供了一个强大的平台.
- 这种技术可以研究皮肤的机械特性及其对光学和介电参数的影响.
- 开发的方法有可能促进皮肤病诊断,化品应用和生物机械研究.
相关概念视频
Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview
360
Attenuated total reflectance (ATR) infrared spectroscopy is a powerful analytical technique used to study the composition of materials. It is widely employed in chemistry, materials science, forensic science, and other fields where sample characterization is required. ATR has several advantages over traditional transmission IR spectroscopy, including the requirement of little to no sample preparation and the ability to analyze a wide range of samples.
The ATR process begins by directing a beam...
The ATR process begins by directing a beam...
360
IR Frequency Region: Fingerprint Region
873
IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
873
IR Spectroscopy: Molecular Vibration Overview
2.1K
When Infrared (IR) radiation passes through a covalently bonded molecule, the bonds transition from lower to higher vibrational levels. The fundamental vibrational motions that result in infrared absorption can be classified as stretching or bending vibrations.
Stretching vibrations are vibrational motions that occur along the bond line, changing the bond length or distance between two bonded atoms. They are further distinguished as symmetric or asymmetric. In symmetric stretching, the...
Stretching vibrations are vibrational motions that occur along the bond line, changing the bond length or distance between two bonded atoms. They are further distinguished as symmetric or asymmetric. In symmetric stretching, the...
2.1K
IR Frequency Region: X–H Stretching
969
In IR spectroscopy, signals produced by the X−H bonds (such as C−H, O−H, or N−H) can be observed in the frequency range of 2700–4000 cm–1. The C−H stretching vibration forms sharp bands in the region 2850–3000 cm–1. The presence of the O−H stretching vibration leads to the forming of an absorption band in the frequency range 3650–3200 cm−1. At the same time, N−H stretching can be confirmed by absorption bands in...
969
Spectrophotometry: Introduction
3.0K
Spectrophotometry is the quantitative measurement of the absorption, reflection, diffraction, or transmission of electromagnetic radiation through a material as a function of the intensity and wavelength of the radiation. A spectrophotometer is a device used to measure the change in the radiation intensity caused by its interaction with the material.
The essential components of a spectrophotometer include a source of electromagnetic radiation, a slot for placing a material to be analyzed, and a...
The essential components of a spectrophotometer include a source of electromagnetic radiation, a slot for placing a material to be analyzed, and a...
3.0K


