探索异常性肺纤维化分子治疗的治疗点
Yue Li1,2,3, Congshan Jiang1, Wenhua Zhu3,4
1National Regional Children's Medical Center (Northwest), Key Laboratory of Precision Medicine to Pediatric Diseases of Shaanxi Province, Xi'an Key Laboratory of Children's Health and Diseases, Shaanxi Institute for Pediatric Diseases, Xi'an Children's Hospital, Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
异形性肺纤维化 (IPF) 研究探索了超越目前药物 (如皮尔芬尼和宁泰达尼布) 的新分子疗法. 本综述涵盖了针对更好的IPF治疗的临床试验中的模型和目标.
科学领域:
- 肺病学和呼吸系统医学
- 翻译医学是一种翻译医学.
- 药物发现 药物发现 药物发现
背景情况:
- 异形性肺纤维化 (IPF) 是一种进展性肺部疾病,治疗选择有限,以表皮损伤和纤维化为特征.
- 目前的治疗方法,pirfenidone和 nintedanib,只能减缓疾病的进展,并且有局限性.
- 肺纤维化也是COVID-19的一个明显并发症.
研究的目的:
- 审查研究平台,包括细胞和动物模型,用于研究异常性肺纤维化分子疗法.
- 检查对IPF有前途的治疗点及其临床试验进展.
- 提供IPF潜在的新型治疗点的前景.
主要方法:
- 审查关于异常性肺纤维化研究模型的现有文献.
- 对针对IPF的分子疗法进行临床试验数据的分析.
- 专注于具有公开临床结果的治疗目标.
主要成果:
- 确定了关键的研究平台:IPF患者研究,细胞模型和动物模型.
- 包括TGF-β,VEGF,PDGF,FGF,LPA,IL-13,ROCK和JAK/STAT通路在内的目标的详细进展.
- 突出了已经进入临床试验的目标,并公布了结果.
结论:
- 目前的IPF治疗方法不足,需要新的分子疗法.
- 不同的研究模型和治疗目标显示出IPF治疗开发的前景.
- 进一步验证新兴标对于潜在地治愈异常性肺纤维化至关重要.
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