对过敏性鼻炎和非过敏性鼻炎的鼻氧化物测量:一个元分析
Ahmad Faiz Dahlan1, Md Asiful Islam2, Norasnieda Md Shukri1
1Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
概括
与对照组和非过敏性鼻炎 (非AR) 患者相比,过敏性鼻炎 (AR) 患者的鼻氧化物 (nNO) 水平更高. 这表明nNO测量可能有助于诊断和管理鼻炎状况.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏和免疫学 过敏和免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 过敏性鼻炎 (AR) 和非过敏性鼻炎 (非AR) 是影响鼻腔通道的常见疾病.
- 准确诊断和管理鼻炎亚型对于患者护理至关重要.
- 鼻氧化 (nNO) 是一种具有潜在诊断和预后价值的生物标志物.
研究的目的:
- 在过敏性鼻炎 (AR) 和非过敏性鼻炎 (非AR) 中对鼻氧化 (nNO) 测量进行元分析和系统审查.
- 为了在AR,非AR和健康的对照组中比较nNO水平.
- 评估nNO在鼻炎管理中的潜在作用.
主要方法:
- 在多个电子数据库 (PubMed,Google Scholar,Scopus,Web of Science,Cochrane) 中进行系统搜索.
- 包括18项用于元分析的研究和20项用于系统审查的研究,共3097名参与者.
- 使用乔安娜·布里格斯研究所工具进行质量评估,并通过漏斗图表进行出版偏差评估.
主要成果:
- 与健康对照组相比,AR患者的nNO水平显著更高.
- 与非AR患者相比,AR患者的nNO水平明显高.
- 在非AR患者和健康对照者之间没有观察到nNO水平的显著差异.
结论:
- 鼻氧化 (nNO) 的测量显示出在过敏和非过敏鼻炎的诊断和管理方面具有前途.
- 需要进一步的研究来确定nNO测量在鼻炎中的临床实用性和益处.
- 高质量的证据支持AR患者的差异性nNO水平.
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