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胎儿先天性肺形的结果:系统性审查和元分析
Filomena Giulia Sileo1,2, Sara Alameddine3, Daniela Anna Iaccarino3
1Prenatal Medicine Unit, Obstetrics and Gynaecology Unit, Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Modena, Italy.
Journal of perinatal medicine
|April 23, 2024
概括
胎儿的先天性肺形 (CLMs) 往往表现为有利的结果,约31%的胎儿在怀孕期间体积退化. 然而,关于胎儿治疗的证据
科学领域:
- 产前诊断和胎儿异常的管理.
- 胎儿医学和产科.
- 儿科外科和肺病学.
背景情况:
- 先天性肺形 (CLMs) 是一个多样化的胎儿肺异常群体.
- 瘤呈现出不同的表现,从无症状的病变到需要干预的严重疾病.
- 产前诊断允许评估子宫内自然史和潜在的干预措施.
研究的目的:
- 系统地审查和对胎儿产前诊断出先天性肺形 (CLMs) 的结果进行元分析.
- 评估CLM的子宫内自然史和演变.
- 评估胎儿治疗对妊娠结果的影响.
主要方法:
- 对Medline,Embase和Cochrane数据库进行系统审查.
- 包括39项研究,包括2638名胎儿与产前诊断的CLM.
- 进行元分析以综合结果数据.
主要成果:
- 31%的CLM显示尺寸回归,而8.5%的CLM则增加.
- 子宫内,新生儿和围产期死亡率分别为1.5%,2.2%,3%.
- 新生儿发病率发生在20.6%的病例中; 46%的新生儿接受了手术. 患有CLM和水的胎儿有42%的胎儿/产周损失率.
结论:
- 在产前诊断出CLM的胎儿通常有良好的结果.
- 关于胎儿治疗在改善CLM结果中的作用的证据质量较低.
- 需要进一步的研究来澄清胎儿干预对CLM的疗效.
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