在缺氧状态下重复的冲刺训练会通过S100A蛋白信号传递诱导特定的骨肌肉适应
Clément Lanfranchi1,2, Sarah J Willis1,3, Louis Laramée1
1Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
概括
在低氧 (RSH) 和正常氧 (RSN) 中重复的冲刺训练产生了类似的性能增长. 然而,RSH独特地激活了骨肌肉中的S100A/Akt通路,这表明运动员有不同的分子适应.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 运动科学 运动科学 运动科学
背景情况:
- 反复冲刺训练 (RST) 在运动员中很常见,缺氧可能会增强效果.
- 驱动骨肌肉适应RST的分子机制在缺氧与正常性缺氧中尚未完全理解.
研究的目的:
- 调查反复冲刺训练在缺氧 (RSH) 与正常性 (RSN) 对骨肌肉代谢适应的影响.
- 为了比较RSH和RSN协议之间的运动性能变化.
主要方法:
- 16名健康男性接受了9次RST疗程,分为RSN (FiO2=0.209) 和RSH (FiO2=0.136) 组.
- 使用重复冲刺能力 (RSA) 和Wingate测试来评估运动表现.
- 骨肌肉的适应性通过蛋白质组学和西部斑在巨大的横向活检上进行了分析.
主要成果:
- 无论是RSN和RSH组,在RSA和Wingate测试性能方面都显示出可比的改善.
- 肌肉分析显示,在两组中,氧化酸化蛋白减少,线粒体生物发生蛋白增加.
- 蛋白质组学在RSH组中发现了增加的S100A家族蛋白质,特别是S100A13,与增强的Akt酸化和蛋白质合成信号相关.
结论:
- RSH和RSN诱导类似的运动性能增强.
- 与RSN相比,RSH会引起骨肌肉中的特定分子适应,包括激活S100A/Akt通路,这可能会导致与RSN相比不同的训练效应.
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