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糖尿病胃肠病的细肠细菌过度生长
Revati Varma1, Subhankar Chakraborty1, Duane D Burton1
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Neurogastroenterology and motility
|April 23, 2024
概括
糖尿病胃肠病症 (DGE) 患者经常出现小肠细菌过度生长 (SIBO). 在脂质挑战期间,SIBO与恶心,腹和胀气的增加有关,但并没有延迟胃排空.
科学领域:
- 胃肠病学 胃肠病学
- 糖尿病学 糖尿病学
- 微生物学 微生物学
背景情况:
- 糖尿病胃肠病 (DGE) 通常与小肠细菌过度生长 (SIBO) 有关.
- 目前的SIBO诊断可能是不可靠的DGE由于改变了肠道过境.
- 在DGE中SIBO的风险因素和后果仍然不清楚.
研究的目的:
- 为了确定在DGE患者中SIBO的流行率.
- 在DGE中识别与SIBO相关的风险因素.
- 评估DGE中SIBO和胃肠道症状之间的关系.
主要方法:
- 在75名DGE患者中,使用十二指管吸入剂来诊断SIBO (≥10^5 CFU/mL).
- 评估了GE和脂质挑战期间的胃排空 (GE) 固体和症状.
- 在两周内,使用经过验证的日记追踪每日症状.
主要成果:
- 在45%的DGE患者中检测到SIBO.
- SIBO与使用质子抑制剂,每日症状或GE参数无关.
- 在脂质挑战期间严重的恶心,腹和胀气与SIBO有显著的关联.
结论:
- SIBO在DGE中普遍存在,并与对脂质的敏感性增加有关.
- 脂质挑战期间的症状,而不是延迟的GE,与DGE中的SIBO相关.
- 细菌产品激活母细胞可能解释SIBO相关DGE的脂质敏感性增加.
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