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相关概念视频

Hematopoiesis01:21

Hematopoiesis

5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

714
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
714
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Production of Formed Elements01:34

Production of Formed Elements

1.4K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.4K

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相关实验视频

Updated: Jun 28, 2025

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
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In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

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造血细胞的克隆进化在空间上发展.

Rebecca Austin1,2, Iannis Aifantis1,2

  • 1Department of Pathology, NYU Grossman School of Medicine, New York, New York.

Blood cancer discovery
|April 23, 2024
PubMed
概括
此摘要是机器生成的。

这项研究表明,骨髓中突变的造血克隆在空间上受到限制. 这些克隆表现出异质的位置,为克隆血液形成提供了新的见解.

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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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相关实验视频

Last Updated: Jun 28, 2025

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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科学领域:

  • 血液学 血液学 血液学
  • 癌症生物学 癌症生物学
  • 空间生物学 空间生物学

背景情况:

  • 骨髓中克隆性血液形成 (CH) 突变的空间分布在很大程度上是未知的.
  • 微环境相互作用在CH进展中的作用需要进一步研究.

研究的目的:

  • 为了研究骨髓中突变克隆的空间分布.
  • 探索携带CH突变的造血克隆的空间约束和异质性.

主要方法:

  • 开发一种新的技术来检查骨髓中突变克隆的空间位置.
  • 对突变造血克隆的空间模式和分布的分析.

主要成果:

  • 证明突变的造血克隆在骨髓内受到空间限制.
  • 提供了突变克隆异质空间位置的第一个证据,发生在毫米范围内.

结论:

  • 突变的造血克隆表现出空间约束和骨髓中不均的分布.
  • 这种空间理解对于未来研究CH机制和微环境相互作用至关重要.