在18F-DCFPyL PSMA PET/CT上减少由于前列腺尿道尿路停滞的错误阳性,使用MRI
David G Gelikman1, Esther Mena1, Liza Lindenberg1
1From the Molecular Imaging Branch.
Clinical nuclear medicine
|April 23, 2024
概括
在前列腺尿道中保留的尿液可以在前列腺特异性膜抗原 (PSMA) PET扫描上模仿前列腺内部病变. 将PSMA PET/CT与T2W MRI结合起来,有助于区分真正的病变与尿道器件.
科学领域:
- 核医学就是核医学.
- 放射学 放射学是一门学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 针对前列腺特异性膜抗原 (PSMA) 的PET放射追踪剂显示在泌尿系统中发生生理吸收.
- 这种吸收可以被误解为前列腺内病变,特别是前列腺尿道.
研究的目的:
- 调查前列腺中线18F-DCFPyL活性与T2加权的MRI超强度之间的相关性.
- 评估前列腺尿道中保留的尿液是假阳性PSMA PET发现的原因.
主要方法:
- 对85名接受了18F-DCFPyLPSMA PET/CT和前列腺MRI的患者进行了回顾性分析.
- 评估中线放射性追踪活性和保留的尿液在空白后T2WMRI上.
- 在有和没有中线活动的患者之间,尿道和前列腺特征的统计比较.
主要成果:
- 在14名患者 (病例组) 观察到中线PSMA PET活性,而71名患者没有中线活性 (对照组).
- 在T2WMRI上尿道超强度在病例组 (71.4%) 与对照组 (29.6%) 相比显著更高 (P < 0.01).
- 中线活动的患者尿道尺寸更大,前列腺体积更大,尿道曲率更高.
结论:
- 前列腺尿道中停滞不前的尿液是PSMA PET成像中的混因素.
- 将PSMA PET/CT与T2W MRI相结合,可以减少前列腺癌的错误阳性解释.
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