SHBG基因多态性及其对血清SHBG的影响,男性的总和自由丸激素度
Joeri Walravens1, Bas Sleumer2,3,4, Michel J Vos4
1Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium.
The Journal of clinical endocrinology and metabolism
|April 23, 2024
概括
性激素结合球蛋白 (SHBG) 的遗传变异会影响男性的总 (T) 和SHBG水平. 然而,这些常见的遗传变异不会显著改变测量的自由水平.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 性激素结合球蛋白 (SHBG) 的遗传变异可以影响性类固醇暴露估计.
- 如果不考虑遗传因素,不准确的自由激素计算可能导致误诊.
研究的目的:
- 检查SHBG遗传变异对男性计算和测量的血清自由 (T) 的影响.
- 研究特定单核酸多形态 (SNP) 对SHBG和水平的流行率和影响.
主要方法:
- 一项基于人口的兄弟姐妹对研究,涉及999名25-45岁的健康男性.
- 影响SHBG或T结合亲缘关系/度的SNP的基因定型.
- 使用免疫试验,LC-MS/MS和平衡透析测量SHBG,总T和自由T.
主要成果:
- 分析的SNP显示出不同的等位基频率 (0.5%58.2%).
- 特定的SNP (例如rs6258,rs6259,rs727428,rs1799941) 显著改变了SHBG和T总度.
- 没有观察到对测量自由T的显著影响,而对于计算自由T的rs6259同胞体,有朝着更高值的趋势.
结论:
- 在SHBG中通常分析的SNP会影响男性的总T和SHBG的血清度.
- 这些遗传变异并没有实质性地影响测量到的自由T水平,除了rss6259同胞细胞的趋势.
- 这些发现强调了考虑SHBG的遗传变异对于准确评估性类固醇状态的重要性.
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