治疗舌癌患者的生存率:一个单一中心的经验
Pablo Veiga-San Roman1, Victor Villanueva San Vicente1, M Angeles Rodriguez-Gonzalez1
1Cirugía Oral y Maxilofacial del Hospital Clínico Universitario Virgen de la Arrixaca Ctra., Madrid-Cartagena, s/n, 30120, El Palmar, Murcia, Spain.
Discover oncology
|April 23, 2024
概括
对于舌头癌症患者来说,透切除边缘显著降低了生存率. 然而,淋巴切除术在这个队列中改善了整体生存率和无病生存结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 癌症研究 癌症研究
背景情况:
- 舌头癌症是一个重大的全球健康挑战.
- 了解预后因素对于优化治疗策略至关重要.
- 以前的研究表明了手术边缘和淋巴结状况的重要性.
研究的目的:
- 评估舌头癌症患者的整体存活率 (OS) 和无病存活率 (DFS).
- 确定影响生存的人口,瘤和手术特征.
- 分析切除边缘和淋巴切除术对患者结局的影响.
主要方法:
- 对205名在2000年至2020年期间接受治疗的初级舌癌患者的回顾性分析.
- 使用Kaplan-Meier方法进行生存分析.
- 逻辑等级测试用于变量比较和考克斯回归用于风险因素识别.
主要成果:
- 总生存率为72.6%,平均14.43年;无病生存率为55.3%,平均9.91年.
- 瘤靠近切除边缘 (HR 2.20) 和透边缘 (HR 3.86) 显著降低了生存率.
- 淋巴切除术与延长生存时间 (HR 0.15) 有关.
结论:
- 透切除边缘是舌头癌存活率的负预后因素.
- 淋巴切除术改善了舌头癌症患者的生存结果.
- 手术技术和淋巴结管理对于改善患者预后至关重要.
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