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肌痛性骨髓灰质炎患者的COVID-19:中国的一项单中心回顾性研究

Jiayi Li¹, Yiming Zheng¹, Yawen Zhao¹

¹Neurology Department, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|April 23, 2024

概括

大多数肌痛性骨髓灰质炎患者患有轻度的COVID-19,但患有并发症和高MG-ADL得分的老年人患重症症状的风险更高. 某些免疫抑制剂也可能增加严重性风险.

科学领域:

神经学神经学
传染性疾病传染性疾病
免疫学免疫学免疫学

背景情况:

骨髓灰质炎 (MG) 患者可能面临2019年新冠肺炎疾病 (COVID-19) 的风险增加.
了解COVID-19对MG患者的影响对于风险评估和管理至关重要.

研究的目的:

为了调查COVID-19和骨髓灰质炎之间的关联.
为了确定MG患者严重COVID-19结局的危险因素.

主要方法:

对134名肌痛性肌痛症患者的回顾性队列研究 (2020年6月至2023年4月).
患者被分为COVID-19和非COVID-19组.
后勤回归分析以确定COVID-19和严重症状的风险因素.

主要成果:

80.6%的MG患者感染了COVID-19,主要是轻度/中度症状 (95.4%).
严重的COVID-19的危险因素包括年龄较大,并发症,rituximab使用,瘤,哈希莫托甲状腺炎和较高的MG-ADL得分.
在COVID-19后增加的MG-ADL得分与干咳,口服皮质类固醇使用和多种免疫抑制剂有关.

结论:

大多数肌痛性骨髓灰质炎患者经历了轻度的COVID-19.
高龄,多种并发症,高MG-ADL得分和广泛的免疫抑制剂使用与MG患者患重症COVID-19症状的风险增加有关.

关键词:

在 COVID-19 疫情中,免疫抑制剂免疫抑制剂骨髓灰质炎 (Myasthenia gravis) 是一个严重的疾病.神经肌肉疾病是一种神经肌肉疾病.疫苗接种疫苗接种

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