与叶酸代谢相关的营养素和结直肠癌风险上的多态性之间的相互作用:巴斯克国家的一项病例对照研究
Sara Corchero-Palacios1, Iker Alegria-Lertxundi1, Marian M de Pancorbo2,3
1Department of Pharmacy and Food Sciences, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz (Araba/Álava), 01006, Spain.
European journal of nutrition
|April 23, 2024
概括
高摄入贝他因可能会降低结肠直肠癌 (CRC) 的风险. 涉及胆,维生素B12和MTHFR/MTHFD1变异的基因饮食相互作用也会影响CRC风险,这表明潜在的营养干预措施.
科学领域:
- 营养流行病学 营养流行病学
- 分子流行病学分子流行病学
- 胃肠病学 胃肠病学
背景情况:
- 叶酸介导的一碳代谢 (FOCM) 在结直肠癌发生过程中至关重要.
- 之前对FOCM基因饮食相互作用和结直肠癌 (CRC) 风险的研究已经产生了不确定的结果.
研究的目的:
- 调查与FOCM相关的饮食因素和遗传变异与CRC风险的关联.
- 探索影响CRC风险的潜在营养基因和营养生活方式相互作用.
主要方法:
- 在229名CRC患者和229名来自肠癌查计划的匹配对照的观察性研究.
- 条件后勤回归分析用于计算几率比率 (OR) 和95%置信区间 (95%CI).
- 对于显著性 (α = 0.005) 应用了邦费罗尼校正.
主要成果:
- 饮食中高摄入贝他因与CRC风险降低有关 (OR:0.21,95% CI:0.10-0.40).
- 在SNP (rs1476413,rs17824591) 和总胆/维生素B12摄入量之间发现了显著的基因饮食相互作用.
- 观察到与总胆 (OR:0.25,95% CI:0.11-0.66) 和维生素B12 (OR:2.48,95% CI:1.04-5.00) 的相互作用.
结论:
- 贝他因摄入量和特定的基因-饮食相互作用 (MTHFR,MTHFD1变异与饮食因素) 可能会影响CRC风险.
- 这些发现表明有针对性的营养干预措施有潜力,以减轻CRC风险.
- 需要进一步的研究来证实这些结果,并为临床策略提供信息.
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