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埃及多动症儿童miRNAs的表达模式:临床研究与相关性分析

Hala M Zeidan¹, Neveen Hassan Nashaat², Maha Hemimi²

¹Research on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, El-Buhouth St., Dokki 12622, Cairo, Egypt. halazeidan@yahoo.com.

Journal of molecular neuroscience : MN

|April 23, 2024

概括

这项研究发现,特定的microRNAs (miRNAs) 和来自大脑的神经营养因子 (BDNF) 显示出作为ADHD生物标志物的潜力. 降低调节的miR-34c-3p和miR-138-1,以及升高的BDNF,可能会导致儿童的ADHD病因.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
生物化学生物化学

背景情况:

注意缺陷/多动障碍 (ADHD) 的病因仍然不完全理解.
微RNA (miRNA) 正在成为各种病理生理条件中的潜在诊断生物标志物和治疗点.
调查特定的miRNA和神经营养因子可能会阐明ADHD机制.

研究的目的:

为了比较ADHD儿童与神经类型对照儿童的miR-34c-3p,miR-155,miR-138-1,miR-296-5p和来自大脑的神经营养因子 (BDNF) 的血水平.
探索这些分子标记物与临床数据之间的相关性,包括认知和行为评估.
评估这些生物标志物的ADHD诊断潜力.

主要方法:

使用定量实时PCR (qRT-PCR) 来测量miRNA表达水平.
酶相关免疫吸收试验 (ELISA) 用于量化血BDNF水平.
标准化的认知和行为尺度 (斯坦福比内特,学前语言尺度,康纳尺度) 用于评估临床特征.

主要成果:

与对照组相比,患有ADHD的儿童的血BDNF水平显著更高 (p=0.0003).
在患有ADHD的儿童中,miR-34c-3p和miR-138-1的表达显著下调 (p<0.01).
miR-296-5p水平与智商得分 (p=0.03) 有负相关性,miR-34c-3p,miR-138-1和BDNF具有良好的诊断潜力.

结论:

下调的miR-34c-3p和miR-138-1,加上高的BDNF,与研究的埃及儿童的ADHD病因有关.
这些分子标记物有望成为ADHD的潜在诊断工具.
观察到性别差异会影响miRNA表达模式,特别是在ADHD儿童中.

关键词:

更多关于 ADHD ADHD 的文章这就是为什么BDNF是BDNF.孩子孩子孩子孩子认知认知是一种认知.性别性别性别性别这是一个微型RNA.

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