睡眠模式的变化,遗传易感性,以及中国发生的心血管疾病
Tingyue Diao1, Kang Liu1,2, Junrui Lyu1
1Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
JAMA network open
|April 23, 2024
概括
在五年内保持良好的睡眠模式可以显著降低心血管疾病 (CVD) 的风险,即使对具有高遗传易感性的个体也是如此. 这突出了睡眠.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 遗传学 遗传学 是一个
背景情况:
- 不断变化的睡眠模式与心血管疾病 (CVD) 发病率之间的联系尚未完全理解.
- 在这种关联中,遗传倾向的潜在改变作用需要进一步研究.
研究的目的:
- 检查睡眠模式五年变化与发生心血管疾病的风险之间的关联.
- 通过多基因风险评分 (PRS) 评估的遗传敏感性是否会改变这些关联.
主要方法:
- 一项前性队列研究,涉及15306名来自东-通吉队列 (2008-2018) 的中国成年人.
- 睡眠模式 (睡觉时间,持续时间,质量,午睡) 在五年内 (2008-2013) 进行了评估.
- 从2013年到2018年使用考克斯回归模型追踪了心血管疾病,冠心病 (CHD) 和中风的发生率.
主要成果:
- 与持续不良的睡眠模式相比,持续有利的睡眠模式与心血管疾病 (HR,0.80),心血管疾病 (HR,0.84) 和中风 (HR,0.66) 的风险降低有关.
- 在心脏病或中风风险的睡眠模式变化和PRS之间没有发现显著的相互作用.
- 然而,良好的睡眠模式与低PRS相结合显示,心脏病 (HR,0.65) 和中风 (HR,0.48) 的风险最低.
结论:
- 保持良好的睡眠模式对于中年和老年人预防心血管疾病至关重要.
- 良好的睡眠对心血管疾病风险的好处即使存在更高的遗传倾向,也仍然存在.
- 这些发现强调了生活方式干预的重要性,特别是改善睡眠,以减轻心血管疾病风险.
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