美国男性阴茎癌的风险和预测因素 携带HIV的退伍军人
Jing Zhao1, Yongquan Dong2,3, Eva Clark2,4
1Section of Epidemiology and Population Sciences, Department of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine.
艾滋病毒感染者 (PWH) 患阴茎癌的风险明显增加. 这包括那些CD4计数低,可检测的病毒载量,或有前科冠状腺瘤的人,强调了有针对性的预防的必要性.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 艾滋病毒感染者 (PWH) 可能面临更高的阴茎癌负担.
- 了解PWH的特定风险对于公共卫生倡议至关重要.
研究的目的:
- 为了评估与普通人群相比,PWH患者的阴茎癌风险.
- 在艾滋病毒 (VWH) 的退伍军人中确定阴茎癌的风险因素.
主要方法:
- 全国追溯匹配队列研究.
- 在44,173名VWH与159,443名没有艾滋病毒的退伍军人中比较阴茎癌发病率.
- 利用考克斯回归模型来估计危险比率和置信区间.
主要成果:
- 艾滋病毒阳性与阴茎癌的风险增加2.63倍有关 (调整HR2.63;95%CI1.64-4.23).
- 调整后的风险增加到4.25倍,当不包括前科冠状腺瘤 (调整后HR4.25;95%CI2.75-6.57).
- 在VWH中,关键的风险因素包括CD4+数量最低点,病毒载量控制不足,以及前科冠状炎.
结论:
- 特别是那些具有特定风险因素的VWH,患阴茎癌的风险较高.
- 对这一群体来说,阴茎癌预防策略至关重要.
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