在三个多个月的ART处方中保持HIV护理:莫桑比克的一项回顾性队列研究
Anna Saura-Lázaro1, Orvalho Augusto2,3,4, Sheila Fernández-Luis1,2
1ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
AIDS (London, England)
|April 23, 2024
概括
三个多个月 (3MMD) 的抗逆转录病毒疗法 (ART) 改善了早期和已建立的注册者的HIV护理保留. 这种方法提高了与莫桑比克每月ART分发相比的患者保留率.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 艾滋病毒/艾滋病研究研究
背景情况:
- 对抗逆转录病毒治疗 (ART) 的坚持对于管理HIV/AIDS至关重要.
- 三个多个月的ART (3MMD) 处方提供了一个潜在的策略,以改善患者在护理中的保留.
- 了解3MMD对不同患者群体的保留的影响,对于优化艾滋病毒护理提供至关重要.
研究的目的:
- 评估ART的3MMD对南莫桑比克艾滋病毒护理保留的有效性.
- 为了比较3MMD患者和每月ART分发的患者之间的保留率.
- 分析3MMD对ART和年龄组的时间分层保留的影响.
主要方法:
- 追溯性队列研究,分析常规健康数据.
- 在2018年1月至2021年3月期间,包括7378名10岁以上的艾滋病毒感染者 (PWH) 开始ART.
- 考克斯的比例风险模型用于比较3MMD和月度发行之间的消耗,分层为早期 (<6个月) 与已建立 (≥6个月) 的注册者以及青少年/青年 (10-24岁) 与成年人 (≥25岁) 的分层.
主要成果:
- 对于既定和早期注册者来说,3MMD与每月分发相比,与较低的消耗率有关.
- 在所有层级的3MMD组中,磨损的调整危险比率 (aHR) 较低.
- 在3MMD中增加消耗风险的因素包括男性性别和较低体积的设施;更长的ART持续时间和更大的年龄 (≥45岁) 降低了消耗风险.
结论:
- 与每月分发相比,每3个多月分发 (3MMD) 的抗逆转录病毒疗法显著改善了艾滋病毒护理的保留率.
- 在早期和成熟的ART注册者中观察到3MMD对保留的好处,尽管在成熟的注册者中更为明显.
- 调查结果支持3MMD战略的更广泛实施,以加强长期艾滋病毒护理参与.
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