在患有甲状腺相关眼科病的人群中,初级视觉皮层的功能连接强度发生变化
Chen-Xing Qi1, Zhi Wen2, Xin Huang3
1School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University.
Neuroreport
|April 23, 2024
概括
与健康对照人群相比,甲状腺相关眼病 (TAO) 患者在初级视觉皮质 (V1) 中表现出功能连接 (FC) 的改变. 这些干扰可能会影响视觉处理和运动功能.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 甲状腺相关的眼病 (TAO) 是一种自身免疫性疾病,影响眼睛和眼道.
- 视力障碍在TAO中很常见,但根本的神经机制尚未完全理解.
- 休息状态功能性MRI (fMRI) 可以揭示大脑内在的功能连接 (FC) 改变.
研究的目的:
- 研究TAO患者和健康对照人群 (HCs) 之间初级视觉皮层 (V1) 内在功能连接 (FC) 的差异.
- 为了确定与TAO相关的特定FC模式.
- 评估这些FC模式在使用机器学习对TAO患者进行分类方面的潜力.
主要方法:
- 休息状态的fMRI对21名TAO患者和21名年龄和性别匹配的HC进行.
- 用功能连接 (FC) 分析来评估V1的内在连接.
- 支持矢量机 (SVM) 模型使用FC改变进行训练,以区分TAO和HC.
主要成果:
- 与HCs相比,TAO患者在左V1和双边骨 (CAL),语言 (LING) 和上尾之间显著减少了FC.
- 在TAO患者的右V1和双边CAL/LING和右小脑之间也观察到降低的FC.
- 使用左V1FC,SVM分类达到61.9%的准确率,使用右V1FC,达到64.29%的准确率.
结论:
- 患有TAO的患者在休息时表现出V1和更高视觉区域之间的内在功能连接被破坏.
- 这些发现表明TAO的上下调制,视觉图像和视觉运动功能的潜在损伤.
- 了解这些神经生物学机制可能有助于解决TAO中的视力障碍.
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