肺部长期COVID的特征和决定因素
Michael John Patton1,2, Donald Benson3, Sarah W Robison4
1Medical Scientist Training Program, Heersink School of Medicine.
JCI insight
|April 23, 2024
概括
持续咳和呼吸短促在长期COVID中很常见. 肺功能测试显示,超过一半的患者患有扩散障碍和限制,特别是那些需要机械通风的人.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 持续咳和呼吸不良是SARS-CoV-2 (长期COVID) 后急性后续症状的标志性症状.
- 肺性长期COVID的生理基础和临床预测因素仍然不完全理解.
研究的目的:
- 描述特征并确定肺性长期COVID的决定因素.
- 调查肺功能测试 (PFT) 和CT成像在评估长期COVID患者中的作用.
主要方法:
- 对929名患有长期COVID和持续性肺部症状的患者的回顾性分析.
- 基于PFT参数的分层:一氧化碳的扩散能力 (DLCO) 和总肺容量 (TLC).
- 多变量回归分析和CT成像子分析.
主要成果:
- 51%的患者表现出扩散障碍 (DLCO ≤80%) 和/或肺部限制 (TLC ≤80%).
- 在急性感染期间的侵入性机械通风显著增加了肺部长期COVID的几率 (aOR = 9.89).
- 电脑图像扫描揭示了肺纤维化在患者的一个子集的证据.
结论:
- 持续扩散受损限制是肺长期COVID的一个关键发现.
- PFT对于评估长期COVID患者长期呼吸道症状至关重要.
- 未来的试验应该利用PFT的综合症状和定量数据来选择患者.
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