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Updated: Jun 28, 2025

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暴露于长期高葡萄糖的INS1细胞中的Glis3的下调有助于与葡萄糖毒性相关的β细胞功能障碍

LilyAnne M Grieve1, Abhya Rani1, Gary T ZeRuth1

  • 1Department of Biological Sciences, Murray State University, Murray, KY, USA.

Islets
|April 23, 2024
PubMed
概括

Glis3 (Glis家族指3) 对于胰腺β细胞功能至关重要. 由于高葡萄糖和氧化压力的下调,会损害胰岛素的产生和β细胞的身份,从而导致2型糖尿病.

关键词:
类似于Glis的3 (Glis3)V-maf 肌肉aponeurotic 纤维肉瘤 瘤基因同类物 a (MafA)葡萄糖毒性 葡萄糖毒性胰岛素调节的方法胰腺β细胞是胰腺β细胞.

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