儿童周期性四肢运动障碍:系统性审查
Lourdes M DelRosso1, Daniel L Picchietti2, Denise Sharon3
1University of California San Francisco, Fresno, CA, USA.
Sleep medicine reviews
|April 23, 2024
概括
儿科周期性四肢运动障碍 (PLMD) 诊断需要特定的标准,包括多睡眠学. 研究强调了诊断和治疗方面的挑战,特别是像ADHD这样的并发症.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 儿科 儿科 儿科
背景情况:
- 儿童的周期性四肢运动障碍 (PLMD) 很少见,约占儿科人口的0.3%.
- 自2003年以来,PLMD的诊断标准已经发展,需要多睡眠学和周期性四肢运动指数 (PLMS指数) ≥5.
- 诊断需要失眠,高睡眠和疲劳等临床后果,不包括伴随疾病引起的睡眠障碍.
研究的目的:
- 系统地审查有关儿科PLMD的科学文献.
- 评估诊断标准,患病率,并发症和治疗策略.
主要方法:
- 在PubMed,EMBASE和Scopus的系统文献搜索中,遵循PRISMA指南.
- 基于PICOS的纳入标准,从最初的331篇文章中产生了17项研究.
- 分析诊断演变,流行数据,并发症 (特别是ADHD) 和治疗方法.
主要成果:
- 在儿童中PLMD的患病率很低 (0.3%),需要严格的诊断标准,包括多睡眠学和PLMS指数≥5.5.
- 伴随性疾病,特别是ADHD和重叠的疾病使诊断复杂化.
- 周期性腿部运动指数具有高灵敏度但低特异性.
- 补充铁是一种主要的治疗方法,但缺乏标准化的评估.
结论:
- 对于各种症状指标和治疗评估,特别是对补充铁的治疗,需要标准化的方法.
- 建议进一步研究精确的方法,以解决儿科PLMD的诊断和治疗复杂性.
- 量化PLMS和客观评估睡眠参数的全面研究对于促进儿童PLMD的理解和管理至关重要.
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